Volume No : Volume: 02 Issue : 9 Year : 2014 Page No: 458-469
Authors : Da-Yong Lu, Ting-Ren Lu, Jin-Yu Che, Hong-Ying Wu
Abstract :
Cancer is the disease with a common pathological feature of unlimited growth and sometimes invasion and metastasis. Some parts of cancer patients are not given proper treatment by conventional cancer treatments. Individualized cancer therapies (ICT) are designed to improve cancer patients’ treatment outcomes. This perspective is to update current and future ICT methods and therapeutic strategies, and give new directions for revising cancer treatment from empirical to technical-assistant therapy. Present understanding and predictions of drug toxicities and responses to tumor growth or metastases in cancer patients are not well-formed, mostly from doctors’ past experience—empirical. There are fundamentally four types of ICT methodologies (i) drug sensitivity testing; (ii) detection of tumor genetic, transcription and molecular information (bioinformatics) from cancer cells in patients, (iii) pharmacogenetics, (iv) individualized antimetastatic therapy. Since different ICT strategies have their own advantages or disadvantages, optimizing utilizations of different ICT strategies need modern insights and are future trends. Persistent investigations and studies are not avoidable. The survival of cancer patients can be improved by many existing strategies of ICT, and clinical cancer therapy will be updated by finding the relationship between cancer biology, pathology and therapy. Deeper understanding these theories and technologies by ICT will surely benefit clinical cancer trials.
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