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Pharmacological and phytochemical screenings of ethanol extract of Leea macrophylla Roxb.

Volume No : Volume: 02 Issue : 5 Year : 2014 Page No: 321-327

Authors : Abdullah Al Faruq, Mohammed Ibrahim, Ayesha Mahmood, M. Mohi Uddin Chowdhury, Ridwan Bin Rashid, Md. Ruhul Kuddus and Mohammad A. Rashid

Abstract :

The antimicrobial, anti-inflammatory, membrane stabilizing and anti-atherothrombosis activities of crude ethanol extract of leaves of Leea macrophylla Roxb. have been investigated. In antimicrobial assay by disc diffusion method, the extract showed mild to moderate antimicrobial activity with zone of inhibition ranging from 9-12 mm and 16-31 mm for test bacteria and fungi, respectively where the growth of Aspergillus niger, Blastomyces dermatidis, Candida albicans, Pityrosporum ovale, Trichophyton sp. Microsporum sp. and Cryptococcus neoformans were strongly inhibited. The extract produced inhibition of protein denaturation and haemolysis by 47.4% and 57.63% in the in vitro anti-inflammatory and membrane stabilization tests, respectively. On the other hand, the crude extract exhibited 20.61% clot lysis compared to the standard streptokinase (SK) (81.53%) in the anti-atherothrombosis activity studies. Preliminary phytochemical screenings with the crude extract revealed the presence of alkaloids, glycosides, tannins, flavonoids, reducing sugars and gums.

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