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How do acute and chronic inflammatory skin diseases arise? Abrief review

Volume No : (2022) Volume: 10 Issue : 46 Year : 2022 Page No: 30

Authors : Sagar N. Ande, Aditi A. Bodakhe, Ravindra L. Bakal, Anil V. Chandewar

Abstract :

Inflammation is a condition inwhich the component of the body becomes red, sore, and swollen due to infectionor injury. Inflammation of the skin is a symptom of the body’s immunological reaction.Redness, heat, irritation, sensitivity, and swelling are all possible symptoms.Skin immune responses are critical for the host’s defense against harmful germs.Deregulated immunological responses, on the other hand, may result in chronicinflammatory skin disorders. Local immune responses are regulated by extensiveinteraction in diverse cellular and microbial components of the skin toguarantee effective host defense, preserve and restore homeostasis, and avoidchronic illness. Inflammation of skin may be acute, such as from a skin infection,or persistent, such as from an autoimmune disorder. Skin inflammation usuallypresents as a rash that may be raised, red, or warm. Some inflammatory rashescause blister or pimple and some may burn, sting, or itch. There are theevidences for the potential role of DNA methylation within the development of chronicinflammatory skin conditions that are limited. Atopic dermatitis, psoriasis,rosacea, leprosy, chronic pruritus, Hidradenitis suppurativa, and chronicurticarial are some skin inflammatory conditions caused due to bacteria,irritants, and allergens; however, the causes and symptom of all these diseasesare different and somewhat similar also as all these are inflammatory diseases.In this review, we discuss some skin inflammatory diseases to understand itspathophysiology in better way.

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