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Medicinal herbs: Why to include in diabetic foot ulcer therapy? A review

Volume No : (2022) Volume: 10 Issue : 46 Year : 2022 Page No: 8

Authors : Sagar N. Ande, Kanchan M. Dhandar, Ravindra L. Bakal

Abstract :

Diabetic foot ulcers (DFUs) are amain diabetes hurdle that causes significant morbidity and mortality. In thefirst 12 months, mortality rates related with the development of DFUs which arepredicted to be 5%, and 5-year mortality rates are estimated to be 42%. In DFUmanagement, surgical debridement, dressings to maintain a moist woundenvironment and exudate control, wound off-loading, vascular evaluation,infection, and glucose control are all typical practices. Even with thisthorough strategy, the results of DFUs can still be improved. To lower DFUhealing times and rate of amputation, several adjuvant therapies have beeninvestigated. Herbal drugs belonging to family Lamiaceae, Caricaceae,liliaceae, Meliaceae, Zingiberaceae, Actinidiaceae, Myrtaceae, Lauraceae,Vitaceae, etc., have chemical constituents which develop the wound healing fastand promotes epithelisation of skin. Species of these families such asRosmarinus officinalis, Carica papaya, Aloe vera, Ampelopsis japonica, Paeoniasuffruticosa, Azadirachta indica, Syzygium cumini, Hylocereus undatus,Calendula officinalis, Curcuma longa, Actinidia deliciosa, and Aegle marmeloscorr. Pennel are beneficial in management of DFU as their chemical constituentsare known for the wound healing mechanism. These drugs have major constituentRosmarinic acid, Papain, Naftoquinones, Nimonin, zingiberene, Curcumin,ascorbic acid, Methylglyoxal, Vitamin A, Vitamin E, and Oligomeric,procyanidins respectively. These constituents   have antioxidant, anti-inflammatory, antimicrobial, antibacterial, and anti-diabeticaction; thus, all these drugs have efficient application in the of diabeticfoot ulcer’s management.

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